Sir George Clerk was born in 1787 and was the eldest son of James Clerk of the East India Company.
In 1798 he inherited the sixth baronet from his uncle, Sir John Clerk. He entered into a political career, standing as MP for Midlothian (Edinburghshire) from 1811 to 1832. Under the Liverpool administration he was appointed as one of the Lords of the Admiralty, which he held until being appointed to Clerk of the Ordnance in 1827.
Some sources describe Sir George has holding this post from 1827 until 1830, though he is only listed in this role in the Royal Kalendar for the year 1828. His career continued within the Tory Party and as a supporter of Sir Robert Peel, later holding roles that included secretary to the Treasury, Vice-President of the Board of Trade and Master of the Royal Mint.
Sir George Clerk died in 1867 at Penicuik House, near Edinburgh.